For use in small & medium breed dogs. Recommended to support healthy teeth, gums and breath odor. The ProDen PlaqueOff key ingredient is 100% natural kelp and is sustainably harvested in the clear, cold waters off the Scandinavian coastline. Clinical trials on our kelp have shown to help reduce plaque and tartar while helping to improve bad breath. The ProDen PlaqueOff key ingredient is 100% natural kelp and is sustainably harvested in the clear, cold waters off the Scandinavian coastline. Clinical trials on our kelp have shown to help reduce plaque and tartar while helping to improve bad breath. Natural & Effective: Contains 100% natural kelp, sustainably harvested from the pristine waters off the Scandinavian coastline. Clinically Studied: Trials show significant reduction in plaque and tartar, while also improving bad breath. VOHC Approved: Trusted by veterinarians for promoting good oral health in dogs. Visible Results: Noticeable improvement in 3-8 weeks when used as directed. Convenient Packaging: Available as 45/90 pcs for Small & Medium Dogs up to 50 lbs and as 45/90 pcs for Large & Giant Breed Dogs 51 lbs +. Made in the USA: High-quality product manufactured in the United States. The only VOHC approved Soft Chew on the market with A.N ProDen®! These treats are a soft edition to our popular and growing brand ProDen PlaqueOff®. Our Soft Chews contain the 100% natural, unique kelp ingredient A.N ProDen®, shown in clinical trials to help control and improve plaque and tartar and to help improve bad breath when used as directed.